1. Qt45: A small polymerase ribozyme that can synthesize itself (www.science.org)
    polymerase ribozymeself-synthesizingdna synthesis
    117 points by ppnpm 6 days | 21 comments
  2. Switch to Claude without starting over (claude.com)
    migrationtransitionchange
    588 points by doener 5 days | 272 comments
  3. Talos: Hardware accelerator for deep convolutional neural networks (talos.wtf)
    artificial intelligencemachine learningcomputer vision
    54 points by llamatheollama 2 days | 22 comments
  4. Show HN: Agent Action Protocol (AAP) – MCP got us started, but is insufficient (github.com)
    13 points by hank2000 2 days | 2 comments
  5. Decoding GPU Efficiency: The FLOPs Fallacy (clockwork.io)
    3 points by gdcohen 1 day | discuss
  6. Regulator contacts Meta over workers watching intimate AI glasses videos (www.bbc.com)
    meta regulationai privacy concernssocial media surveillance
    51 points by csomar about 19 hours | 10 comments
  7. Why is the first C++ (m)allocation always 72 KB? (joelsiks.com)
    c++ memory allocationmalloclinker magic
    131 points by joelsiks 5 days | 36 comments
  8. In 1985 Maxell built a bunch of life-size robots for its bad floppy ad (buttondown.com)
    4 points by rfarley04 1 day | discuss
  9. U.S. science agency moves to restrict foreign scientists from its labs (www.science.org)
    national science foundationforeign scientistsresearch restriction
    364 points by JeanKage 4 days | 347 comments
  10. New iron nanomaterial wipes out cancer cells without harming healthy tissue (www.sciencedaily.com)
    cancer treatmentiron nanoparticlestargeted therapy
    321 points by gradus_ad 4 days | 106 comments
  11. Court finds Fourth Amendment doesn’t support broad search of protesters’ devices (www.eff.org)
    4th amendmentprotest rightsdigital privacy
    640 points by hn_acker 6 days | 111 comments
  12. Exploiting Iran: A Political Timeline (github.com)
    us-iran relationsmiddle east politicsinternational affairs
    29 points by jamesgill 3 days | 6 comments
  13. Rust is just a tool (lewiscampbell.tech)
    software developmentprogramming languagescareer advice
    170 points by JuniperMesos 6 days | 197 comments
  14. Iran's Ayatollah Ali Khamenei is killed in Israeli strike, ending 36-year rule (www.npr.org)
    ayatollah ali khameneiiranian leadershipmiddle east politics
    473 points by andsoitis 5 days | 922 comments
  15. Tove Jansson's criticized illustrations of The Hobbit (2023) (tovejansson.com)
    223 points by abelanger 6 days | 122 comments
  16. Circle Games (2019) (srconstantin.wordpress.com)
    9 points by surprisetalk 4 days | 2 comments
  17. Qwen3.5 122B and 35B models offer Sonnet 4.5 performance on local computers (venturebeat.com)
    "gpu computingworkstation performancecomputer hardware updates"
    461 points by lostmsu 5 days | 271 comments
  18. When does MCP make sense vs CLI? (ejholmes.github.io)
    microsoft command promptcommand line interfacelegacy technology
    443 points by ejholmes 4 days | 284 comments
  19. Earthquake-Proof Foundations (practical.engineering)
    6 points by vismit2000 1 day | discuss
  20. How did MS-DOS decide on two seconds to keep the floppy disk cache valid? (devblogs.microsoft.com)
    floppy disk cachems-dossoftware development
    15 points by paulmooreparks 2 days | discuss
  21. Anthropic's AI tool Claude central to U.S. campaign in Iran, amid a bitter feud (www.washingtonpost.com)
    artificial intelligenceiran relationsus foreign policy
    27 points by spenvo 1 day | 9 comments
  22. Statement on the comments from Secretary of War Pete Hegseth (www.anthropic.com)
    lost in spacespace explorationcosmic mysteries
    1169 points by surprisetalk 6 days | 357 comments
  23. Allocating on the Stack (go.dev)
    stack allocationmemory managementgo programming language
    169 points by spacey 6 days | 54 comments
  24. Felix "fx" Lindner has died (blog.recurity-labs.com)
    cybersecurityhackingobituaries
    133 points by is_taken 3 days | 35 comments
  25. Senate fails to block US involvement in Iran war (www.usatoday.com)
    iran warsenate voteus military involvement
    32 points by geox about 23 hours | 11 comments
  26. Dear Meta Smart Glasses Wearers: You're Being Watched, Too (gizmodo.com)
    9 points by pabs3 about 18 hours | 1 comments
  27. Let's discuss sandbox isolation (www.shayon.dev)
    dockercontainerizationisolation
    173 points by shayonj 6 days | 69 comments
  28. Running Llama Inference on Intel Itanium (medium.com)
    4 points by RobotToaster 1 day | discuss
  29. Show HN: We want to displace Notion with collaborative Markdown files (www.moment.dev)
    collaborative note takingmarkdown filesproductivity tools
    27 points by antics 2 days | 12 comments
  30. Show HN: Visual Lambda Calculus – a thesis project (2008) revived for the web (github.com)
    49 points by bntr 6 days | 9 comments
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