1. Use of Bayesian methodology in clinical trials of drug and biological products [pdf] (www.fda.gov)
    bayesian methodologyclinical trialsdrug development
    57 points by brendanashworth about 23 hours | 17 comments
  2. San Francisco to offer free childcare to people making up to $230000 (www.theguardian.com)
    11 points by darth_avocado about 1 hour | 1 comments
  3. 25 Years of Wikipedia (wikipedia25.org)
    online historyinternet milestonesdigital archives
    475 points by easton about 17 hours | 387 comments
  4. Ask HN: Share your personal website
    850 points by susam 1 day | 2229 comments
  5. Claude Cowork runs Linux VM via Apple virtualization framework (gist.github.com)
    virtualizationapplelinux
    102 points by jumploops 2 days | 37 comments
  6. A Unique Performance Optimization for a 3D Geometry Language (cprimozic.net)
    28 points by Ameo 5 days | 2 comments
  7. Show HN: TinyCity – A tiny city SIM for MicroPython (Thumby micro console) (github.com)
    micropythonthumbygaming
    125 points by inflam52 about 16 hours | 22 comments
  8. Design and Implementation of Sprites (fly.io)
    graphics designgame developmentanimation techniques
    141 points by sethev about 14 hours | 100 comments
  9. Playing Arcade Mahjong at Home? Or is it just a Mirage? (nicole.express)
    13 points by nicole_express 4 days | 7 comments
  10. Tldraw pauses external contributions due to AI slop (github.com)
    artificial intelligencesoftware developmentopen source
    71 points by pranav_rajs about 6 hours | 23 comments
  11. Show HN: Tabstack – Browser infrastructure for AI agents (by Mozilla)
    108 points by MrTravisB 1 day | 20 comments
  12. How I learned everything I know about programming (agentultra.com)
    self-taught codingsoftware development journeyprogrammer's education
    56 points by speckx about 10 hours | 36 comments
  13. Remails: A European Mail Transfer Agent (tweedegolf.nl)
    email servicesemail technologymessaging platforms
    32 points by Flundstrom2 about 8 hours | 4 comments
  14. Noninvasive brain treatment for depression proves helpful (www.cnn.com)
    13 points by 1659447091 about 2 hours | discuss
  15. The 3D Software Rendering Technology of 1998's Thief: The Dark Project (2019) (nothings.org)
    thief the dark project3d software renderingretro gaming technology
    138 points by suioir about 19 hours | 54 comments
  16. Ask HN: One IP, multiple unrealistic locations worldwide hitting my website
    35 points by nacho-daddy about 12 hours | 15 comments
  17. The <Geolocation> HTML Element (developer.chrome.com)
    html5 geolocationweb developmentbrowser apis
    105 points by enz 2 days | 59 comments
  18. Ask HN: How are you doing RAG locally?
    361 points by tmaly 1 day | 144 comments
  19. America's Throwaway Spies: How the CIA Failed Iranian Informants in Tehran (www.reuters.com)
    7 points by koolhead17 about 1 hour | discuss
  20. Show HN: Control Claude permissions using a cloud-based decision table UI (github.com)
    12 points by sidgarimella about 12 hours | 8 comments
  21. The URL shortener that makes your links look as suspicious as possible (creepylink.com)
    url shortenerslink optimizationblack hat seo
    770 points by dreadsword 1 day | 143 comments
  22. The Executive Assistant Paradox: Why AI Makes This Role Critical, Not Obsolete (vleech.substack.com)
    3 points by connor11528 44 minutes | discuss
  23. Have Taken Up Farming (dylan.gr)
    bob dylan's farming journeysustainable livingcelebrity entrepreneurship
    205 points by djnaraps about 22 hours | 131 comments
  24. Sinclair C5 (en.wikipedia.org)
    electric vehiclesretro technologyconsumer electronics
    88 points by jszymborski 5 days | 56 comments
  25. Show HN: Sparrow-1 – Audio-native model for human-level turn-taking without ASR (www.tavus.io)
    ai model developmentturn-taking technologyspeech recognition
    116 points by code_brian 1 day | 47 comments
  26. Handy – Free open source speech-to-text app (github.com)
    speech-to-textfree open source softwarevoice recognition
    213 points by tin7in 1 day | 102 comments
  27. U.S. carbon pollution rose in 2025, a reversal from prior years (www.nbcnews.com)
    us carbon pollutionemissions riseclimate change
    60 points by gmays about 8 hours | 19 comments
  28. We Gave Our Browser Agent a 3MB Data Warehouse (100x.bot)
    11 points by shardullavekar about 14 hours | 2 comments
  29. Show HN: Tusk Drift – Turn production traffic into API tests (github.com)
    api testingdevopstraffic engineering
    20 points by jy-tan about 11 hours | discuss
  30. Z80 Mem­ber­ship Card (sunrise-ev.com)
    102 points by exvi 4 days | 31 comments
More