1. Use of Bayesian methodology in clinical trials of drug and biological products [pdf] (www.fda.gov)
    bayesian methodologyclinical trialsdrug development
    67 points by brendanashworth 2 days | 19 comments
  2. Claude Cowork exfiltrates files (www.promptarmor.com)
    data breachcybersecurity incidentinsider threat
    860 points by takira 2 days | 394 comments
  3. Why senior engineers let bad projects fail (lalitm.com)
    senior engineer failureproject management mistakessoftware development issues
    256 points by SupremumLimit 1 day | 160 comments
  4. Claude Cowork runs Linux VM via Apple virtualization framework (gist.github.com)
    virtualizationapplelinux
    115 points by jumploops 3 days | 45 comments
  5. Show HN: Reversing YouTube’s “Most Replayed” Graph (priyavr.at)
    reversingyoutubedata analysis
    79 points by prvt 1 day | 21 comments
  6. Show HN: Sparrow-1 – Audio-native model for human-level turn-taking without ASR (www.tavus.io)
    ai model developmentturn-taking technologyspeech recognition
    120 points by code_brian 2 days | 48 comments
  7. Show HN: OpenWork – An open-source alternative to Claude Cowork (github.com)
    open-source coworking softwarecollaboration toolsremote work platform
    220 points by ben_talent 3 days | 53 comments
  8. Show HN: Tabstack – Browser infrastructure for AI agents (by Mozilla)
    124 points by MrTravisB 2 days | 23 comments
  9. OpenAI Introduces Ads to ChatGPT (twitter.com)
    chatgpt adsopenai monetizationai marketing
    16 points by strzalek about 7 hours | 5 comments
  10. Ask HN: How have you or your firm made money with LLMs?
    7 points by bwestergard about 12 hours | 7 comments
  11. My Gripes with Prolog (buttondown.com)
    logic programmingartificial intelligencecomputer science
    149 points by azhenley 1 day | 96 comments
  12. Building a MCP Client in Google Apps Script (justin.poehnelt.com)
    3 points by justinwp about 10 hours | 1 comments
  13. The State of OpenSSL for pyca/cryptography (cryptography.io)
    opensslpythoncryptography
    210 points by SGran 2 days | 57 comments
  14. Tell HN: YouTube gave my username switzerland to a half government organization
    19 points by faebi about 17 hours | 5 comments
  15. Data is the only moat (frontierai.substack.com)
    moatscompetitive advantagebusiness strategy
    198 points by cgwu 1 day | 47 comments
  16. First impressions of Claude Cowork (simonw.substack.com)
    cooperative learningteam buildingoffice dynamics
    228 points by stosssik 3 days | 133 comments
  17. Canada slashes 100% tariffs on Chinese EVs to 6% (electrek.co)
    tariffselectric vehiclesinternational trade
    402 points by 1970-01-01 about 12 hours | 533 comments
  18. Ask HN: What did you find out or explore today?
    212 points by blahaj 2 days | 396 comments
  19. Show HN: Webctl – Browser automation for agents based on CLI instead of MCP (github.com)
    browser automationweb ctlcli tools
    131 points by cosinusalpha 3 days | 36 comments
  20. JuiceFS is a distributed POSIX file system built on top of Redis and S3 (github.com)
    redis file systemdistributed storagecloud-native filesystem
    178 points by tosh 1 day | 105 comments
  21. The Toxic Modernity Narrative (www.theargumentmag.com)
    toxic modernitycultural critiquesocial commentary
    18 points by honoredb about 10 hours | 6 comments
  22. OpenAI Asking Contractors to Upload Work from Past Jobs to Evaluate AI Agents (www.wired.com)
    14 points by rbanffy about 9 hours | 2 comments
  23. Bubblewrap: A nimble way to prevent agents from accessing your .env files (patrickmccanna.net)
    .dotenvenvironment variablessecurity best practices
    180 points by 0o_MrPatrick_o0 2 days | 134 comments
  24. Show HN: I built a text-based business simulator to replace video courses (www.core-mba.pro)
    text-based learningbusiness simulationalternative education
    86 points by Core_Dev 1 day | 60 comments
  25. Sun Position Calculator (drajmarsh.bitbucket.io)
    solar calculationspositioning toolsastronomy
    163 points by sanbor 2 days | 36 comments
  26. The Z80 Mem­ber­ship Card (2015) (sunrise-ev.com)
    105 points by exvi 5 days | 35 comments
  27. Ads Are Coming to ChatGPT. Here’s How They’ll Work (www.wired.com)
    chatgpt advertisingconversational commerceai marketing
    21 points by thm about 11 hours | 10 comments
  28. A Unique Performance Optimization for a 3D Geometry Language (cprimozic.net)
    34 points by Ameo 6 days | 3 comments
  29. Starlink updates Privacy Policy to allow AI model training with personal data (coywolf.com)
    personal datastarlink updatesai model training
    48 points by speckx about 13 hours | 10 comments
  30. White House seeks emergency power auction for largest US electric grid (www.reuters.com)
    grid managementemergency powerelectric grid operations
    15 points by bikenaga about 8 hours | 7 comments
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