1. Malus – Clean Room as a Service (malus.sh)
    clean room servicespharmaceutical compliancegmp facilities
    771 points by microflash about 6 hours | 303 comments
  2. Bubble Sorted Amen Break (parametricavocado.itch.io)
    breakbeatselectronic musicjazz fusion
    146 points by eieio about 3 hours | 56 comments
  3. An old photo of a large BBS (rachelbythebay.com)
    bbsretro technologyvintage computing
    22 points by xbryanx 30 minutes | 7 comments
  4. ATMs didn't kill bank teller jobs, but the iPhone did (davidoks.blog)
    banking technologyjob automationmobile payments
    198 points by colinprince about 5 hours | 246 comments
  5. Reversing memory loss via gut-brain communication (med.stanford.edu)
    gut-brain axismemory lossneuroplasticity
    107 points by mustaphah about 4 hours | 27 comments
  6. Launch HN: IonRouter (YC W26) – High-throughput, low-cost inference (ionrouter.io)
    machine learningnatural language processingdeep learning
    18 points by vshah1016 about 1 hour | 4 comments
  7. The Met Releases High-Def 3D Scans of 140 Famous Art Objects (www.openculture.com)
    art historymuseum technologycultural preservation
    132 points by coloneltcb about 4 hours | 28 comments
  8. Show HN: OneCLI – Vault for AI Agents in Rust (github.com)
    aimachine learningcommand line interface
    79 points by guyb3 about 4 hours | 28 comments
  9. White House plan to break up iconic U.S. climate lab moves forward (www.science.org)
    climate labus researchenvironmental policy
    74 points by robtherobber about 1 hour | 25 comments
  10. Show HN: Understudy – Teach a desktop agent by demonstrating a task once (github.com)
    machine learningai assistanttask automation
    45 points by bayes-song about 3 hours | 11 comments
  11. US banks' exposure to private credit hits $300B (2025) (alternativecreditinvestor.com)
    private creditus bankingcredit market
    203 points by JumpCrisscross about 7 hours | 133 comments
  12. Converge (YC S23) Is Hiring a Founding Platform Engineer (NYC, Onsite) (www.runconverge.com)
    about 3 hours
  13. Asia rolls out 4-day weeks, WFH to solve fuel crisis caused by Iran war (fortune.com)
    work-life balanceremote workfuel crisis
    327 points by speckx about 5 hours | 239 comments
  14. Dolphin Progress Release 2603 (dolphin-emu.org)
    game emulationretro gaminglinux software
    252 points by BitPirate about 11 hours | 41 comments
  15. Kotlin creator's new language: a formal way to talk to LLMs instead of English (codespeak.dev)
    llm interactionnatural language processingkotlin development
    233 points by souvlakee about 6 hours | 192 comments
  16. WolfIP: Lightweight TCP/IP stack with no dynamic memory allocations (github.com)
    network programmingembedded systemslinux development
    46 points by 789c789c789c about 5 hours | 5 comments
  17. Show HN: Axe – A 12MB binary that replaces your AI framework (github.com)
    ai framework replacementmachine learning optimizationsoftware engineering innovation
    87 points by jrswab about 6 hours | 68 comments
  18. The Emotional Labor Behind AI Intimacy (2025) [pdf] (data-workers.org)
    artificial intelligencedata labelinglabor rights
    33 points by beepbooptheory about 4 hours | 8 comments
  19. Show HN: Rudel – Claude Code Session Analytics (github.com)
    aimachine learningchatbots
    114 points by keks0r about 7 hours | 69 comments
  20. The Cost of Indirection in Rust (blog.sebastiansastre.co)
    60 points by sebastianconcpt 3 days | 25 comments
  21. Full Spectrum and Infrared Photography (timstr.website)
    31 points by alter_igel 4 days | 11 comments
  22. DDR4 Sdram – Initialization, Training and Calibration (www.systemverilog.io)
    30 points by todsacerdoti 3 days | 3 comments
  23. Italian prosecutors seek trial for Amazon, 4 execs in alleged $1.4B tax evasion (www.reuters.com)
    amazon taxesitalian taxationcorporate accounting scandals
    176 points by amarcheschi about 5 hours | 47 comments
  24. The Biggest Identity Sandpiles and How to Compute Them (eavan.blog)
    9 points by eavan0 4 days | 6 comments
  25. Contextual commits – An open standard for capturing the why in Git history (vidimitrov.substack.com)
    git historysoftware development toolscontextual data capture
    19 points by vidimitrov about 3 hours | 16 comments
  26. Show HN: Web-based ANSI art viewer (sure.is)
    17 points by lubujackson 2 days | 5 comments
  27. Long Overlooked as Crucial to Life, Fungi Start to Get Their Due (e360.yale.edu)
    fungal kingdommycologymicrobiome
    52 points by speckx about 7 hours | 10 comments
  28. Apple's MacBook Neo makes repairs easier and cheaper than other MacBooks (arstechnica.com)
    repairable electronicssustainable consumptionapple laptops
    108 points by GeekyBear about 3 hours | 54 comments
  29. Claude now creates interactive charts, diagrams and visualizations (claude.com)
    data visualizationcharting softwaregraphic design tools
    130 points by adocomplete about 4 hours | 72 comments
  30. 3D-Knitting: The Ultimate Guide (www.oliver-charles.com)
    3d knittingknitting technologyyarn crafting
    202 points by ChadNauseam about 12 hours | 75 comments
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